How to choose an allergy medicine

There is no single best allergy medicine. The right one depends on your main symptom, your age and whether you need to stay alert. Here is what each label says, side by side.

The seven most common options

Medicine Generic Type Drowsiness (label) How often Ages
Zyrtec cetirizine Oral antihistamine (pill) May cause drowsiness Once a day 6+
Claritin loratadine Oral antihistamine (pill) Labeled non-drowsy Once a day 6+
Allegra fexofenadine Oral antihistamine (pill) No drowsiness warning Once a day (180 mg) or twice a day (60 mg) 12+
Xyzal levocetirizine Oral antihistamine (pill) May cause drowsiness Once a day, in the evening 6+
Benadryl diphenhydramine Oral antihistamine (pill), older type Marked drowsiness Every 4 to 6 hours 6+
Flonase fluticasone propionate Steroid nasal spray No drowsiness warning Once a day 4+
Nasacort triamcinolone acetonide Steroid nasal spray No drowsiness warning Once a day 2+

Start with your main symptom

  • Stuffy nose (congestion): of these, only the steroid nasal sprays, Flonase and Nasacort, list nasal congestion among their uses. Their labels say full relief takes several days to a week of daily use.
  • Sneezing, runny nose, itchy eyes: every antihistamine here lists these. Flonase also lists itchy, watery eyes.

Then think about drowsiness

Check the age on the label

Labels set the youngest age for each product. See allergy medicine for kids.

Generic is the same medicine

Store brands list their active ingredient on the label. Cetirizine is Zyrtec's, loratadine is Claritin's, fexofenadine is Allegra's, levocetirizine is Xyzal's, diphenhydramine is Benadryl's, fluticasone propionate is Flonase's and triamcinolone is Nasacort's.

Not sure? Try the allergy medicine finder or ask a pharmacist. This site summarizes labels and is not medical advice.

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